University of Minnesota
https://twin-cities.umn.edu/
612-625-5000
Milestone
2.4.a

Longitudinal clinical studies

Completed
Ongoing

Establish ongoing longitudinal clinical studies to follow cohorts of different age-groups in various geographic locations to enable characterization of immune responses to naturally occurring influenza infection and vaccination over time. 

Progress Highlights

NCT05436184 (IMPRINT: Immunological memory to prior influenza over time): NIAID- and Open Philanthropy-funded Infant Immunome and Influenza Cohort establishes a long-term, prospective observational cohorts in the US and Mexico to examine immune responses to the infants’ initial influenza exposure (vaccine or infection) and subsequent influenza exposures. 

See research
 

DIVINCI (Dissection of Influenza Vaccination and Infection for Childhood Immunity) establishes a consortium of birth cohort studies in Nicaragua, New Zealand and the US to evaluate mechanisms of imprinting, determine what constitutes protective immunity in early and subsequent influenza infections, including the effects of vaccination, and identify B- and T-cell correlates of protection. 

See research

Nguyen 2026 analyzed historic influenza vaccination cohorts of young and older adults from 1994 and assessed future immune responses spanning three decades of differentially evolving influenza subtypes encompassing H1N1, H3N2, and IBV; the data provided evidence for boosting of vaccine-specific and cross-reactive memory B cell responses, particularly for H1 and IBV future strains, as well as reduced H3N2 responses against future influenza strains spanning three decades. 

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NCT05518500 will prospectively profile immune responses to seasonal influenza vaccine in a cohort of 75 older adults over three annual influenza seasons to identify mechanisms that lead to a loss of response to the vaccines over time.

See clinical trial record
 

NCT05108818, a clinical trial led by the University of Pennsylvania, establishes a NIAID-sponsored long-term cohort study designed to measure influenza virus cellular and humoral immune responses in individuals of different birth years before and after influenza vaccination. 

See clinical trial record