Milestone
2.6.b
Myeloid and lymphoid cell differentiation
In progress
Clarify drivers of myeloid and lymphoid cell differentiation and migration to protect the upper and/or lower respiratory airway and determine how this information can be translated into vaccine R&D.
Progress Highlights
Madissoon 2023 profiled 5 proximal-to-distal locations of healthy human lungs using multi-omic single cell/nuclei and spatial transcriptomics (lungcellatlas.org); identified 80 cell types/states from >190,000 cells including 11 new cell types and discovered new anatomical compartments s, providing a survival niche for IgA plasma cells in the airway submucosal glands.