Promote the development and standardization of immunologic tools to inform the development of universal, broadly protective, and next-generation influenza vaccines.

Gain better understanding of human immunology to inform influenza vaccine development through research focused on new tools and technologies.

Improve understanding of aspects of the B-cell immune response to influenza infection and vaccination that are important for developing better vaccines and optimal strategies for vaccination, particularly in the context of partial preexisting immunity from continual exposure to influenza viruses.

Determine the impact of prior influenza virus infection or vaccination on future immune responses to influenza viruses or vaccines.

Clarify the role of T cells in generating or supporting protective immunity to influenza virus infection and/or vaccination.

Improve understanding of the role of mucosal immunity in protecting against influenza.

Develop novel correlates of protection for assessing seasonal influenza vaccines and broadly protective or universal influenza vaccines as part of clinical studies that demonstrate efficacy against a disease endpoint.