Waldock 2023 (FLUCOP Consortium) conducted a head-to-head comparison of harmonized HAI and MN protocols to evaluate the relationship between HAI and MN titers, and the impact of assay harmonization and standardization on inter-laboratory variability, and agreement between these methods.
Milestone
2.7.c
Immune marker comparisons
In progress
High priority
Conduct side-by-side standardized comparative studies of immune markers, beyond serum HAI titers, as potential correlates of protection in vaccine efficacy/effectiveness studies or in studies that use a controlled human influenza virus infection model.