Cortese 2025 used systems vaccinology to identify factors influencing the magnitude and durability of Ab responses in humans to H5N1 vaccine with and without AS03 adjuvant. The findings suggested a platelet-associated signature that predicted Ab response longevity, highlighting a conserved mechanism for vaccine durability.
Arroyo-Diaz 2023 investigated the mechanisms that control lung-resident memory B-cell responses after intranasal influenza virus infection.
Robinson 2023 analyzed the turnover and persistence of antigen-secreting plasma cells, which produce antibodies that underlie multiple forms of long-lasting immunity, in different tissues and at different ages. Results inform the understanding of the establishment and maintenance of long-lived humoral immunity.
Langley 2022 examined the contribution of memory B-cells to the maintenance of virus-specific antibody levels following acute influenza virus infection in the murine model; data showed that virus-specific plasma cells in the bone marrow are intrinsically long-lived and can maintain serum antibody titers for extended periods of time without requiring significant replenishment from memory B-cells.
Swain 2021 examined mechanisms underlying CD4 T- and B-cell effector responses and memory after influenza virus infection and found that CD4 T-cells require strong initial and extended signals from antigen and pathogen recognition to drive memory and specialized CD4 effectors (such as T follicular helper cell generation).