University of Minnesota
https://twin-cities.umn.edu/
612-625-5000
Milestone
2.7.b

Mucosal immunity correlates

In progress
High priority

Develop correlates of protection for mucosal immunity based on different vaccine platforms (e.g., live-attenuated influenza virus) and routes of administration (e.g., intranasal). 

Progress Highlights

Rattan 2022 developed a mouse model of intranasal infection with influenza B virus to analyze the localization of infection-elicited virus-specific CD4 T cells in secondary lymphoid tissues and lung and examined the distribution of IBV-specific CD4 T cells in lung sub-compartments. 

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McIlwain 2021 identified new single and multi-variable cellular correlates of protection following oral vaccination with an Ad5-based influenza vaccine candidate (Vaxart VXA-A1.1). The authors found that XA-A1.1 elicits mucosal homing cell subsets that correlate with protection. 

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Bean 2024 conducted a CHIVIM study in vaccinated and unvaccinated healthy volunteers to investigate mucosal and systemic immunity after influenza vaccination and infection. They found that correlations between mucosal IgA and serum IgG against specific antigens were low, whether before or after challenge, suggesting a compartmentalization of immune responses. 

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