Milestone
6.4.d
Clinical endpoints for severe disease
In progress
Develop consensus definitions on clinical endpoints for severe influenza disease in vaccine efficacy studies.
Progress Highlights
Braunfeld 2022 found that among pediatric influenza vaccine efficacy trials, primary outcome measures and clinical specimen collection criteria were highly variable; policy and implementation decisions based on VE data are limited, given the absence of influenza vaccination programs in most LMICs.