Kanekiyo 2023 refined the lethal H5N1 infection macaque model to assess the relationship between inhaled dose and disease course, and to evaluate whether vaccination against seasonal influenza using an adjuvanted QIV could offer protection from mortality and/or morbidity caused by the HPAI H5N1 infection in macaques.
Milestone
5.1.f
Predictive value
In progress
High priority
Review a comprehensive analysis of the predictive value of different animal models, including natural hosts such as pigs and horses, for influenza vaccine studies (for both seasonal and broadly protective vaccines).
Progress Highlights
Yuan 2023 developed swine model system (pregnant sow-neonate model) to evaluate the impact of influenza vaccination on maternal immunity and fetal/neonatal development.
Dibben 2021 defined a low, ferret-appropriate vaccine dose for LAIV, suggesting a key role for the ferret model in dose optimization and LAIV strain selection.